Dog Diseases Database
Every hereditary and common canine condition — with tests, affected body regions, and the breeds where each shows up most.
Filters
- HighGeneral / metabolicAutosomal recessive
Primary Ciliary Dyskinesia(RIPD)
This is an inherited respiratory disease passed down in an autosomal-recessive manner, meaning a puppy must inherit the gene variant from both parents to be affected. It is caused by a genetic variant in the AKNA gene, which leads to recurrent and severe inflammation of the lung tissue. The condition affects the respiratory system, impairing the lungs' ability to function properly and leading to frequent infections.
View details - HighSkin & coatAutosomal recessive
Primary Ciliary Dyskinesia (PCD)(PCD)
Primary ciliary dyskinesia is an inherited genetic disorder affecting the respiratory system. It causes the microscopic, hair-like structures called cilia that line the airways to be malformed or unable to move properly. Because these cilia cannot sweep away mucus and debris, the dog's lungs and nasal passages become chronically congested and prone to infection.
Tested via: DNA testView details - SevereSkin & coatAutosomal recessive
Primary ciliary dyskinesia (PCD), STK36-related(PCD)
Primary ciliary dyskinesia is an inherited disorder affecting the respiratory system. It causes dysfunction in the cilia, which are tiny, hair-like structures lining the airways that normally sweep away mucus, dust, and bacteria. Without functioning cilia, the lungs cannot clear themselves, leading to chronic airway inflammation and recurrent infections.
Tested via: DNA testView details - SevereGeneral / metabolicAutosomal recessive
Primary Hyperoxaluria Type I (Oxalosis I)(PH1)
Primary Hyperoxaluria Type I is a severe, inherited metabolic disorder affecting the liver and kidneys. Due to a missing liver enzyme, the body overproduces oxalic acid, which combines with calcium to form hard crystals in the kidneys. These crystals cause rapid, progressive damage to the urinary system and kidney tissues.
View details - MildGeneral / metabolicPolygenic
Prognathism
Prognathism, commonly known as an undershot jaw, is a skeletal malformation of the skull where the lower jaw grows longer than the upper jaw. This structural imbalance affects the dental and skeletal systems, preventing the upper and lower teeth from aligning into a normal bite. The condition is polygenic, meaning it is influenced by multiple genes, and is diagnosed through a thorough examination of the oral cavity.
View details - SevereHead / nervous systemAutosomal recessive
Progressive ataxia with head tremor and seizures
This is a severe, progressive disorder of the nervous system characterized by the premature death of nerve cells in the brain, particularly within the cerebellum, which controls balance and movement. The disease is associated with unusual microscopic structures, called inclusions, that build up inside these nerve cells. This cellular damage leads to a gradual loss of physical coordination and body control.
View details - SevereHead / nervous systemAutosomal recessive
Progressive Axonopathy(PA)
Progressive axonopathy is an inherited neurological disorder where the nerve fibers, known as axons, in the spinal cord gradually deteriorate. These axons act as the communication lines that transmit signals between the brain and the muscles. When they degenerate, the brain can no longer properly control the dog's movements.
View details - SevereSpineAutosomal recessive
Progressive degenerative myeloencephalopathy, PNPLA8-related
This is a severe inherited disease of the central nervous system, specifically affecting the brain and spinal cord. It is caused by a genetic mutation in the PNPLA8 gene, which leads to the progressive breakdown and loss of nerve tissue. As this nerve tissue degenerates, the brain's ability to communicate with the rest of the body is gradually lost.
Tested via: DNA testView details - SevereHead / nervous systemAutosomal recessive
Progressive early-onset cerebellar ataxia, SEL1L-related
This is a severe, inherited neurological disease, often abbreviated as FHA, that affects the cerebellum, which is the part of the brain responsible for coordinating movement. A genetic mutation in the SEL1L gene disrupts normal protein metabolism within cells, leading to the progressive degeneration and loss of vital nerve cells.
View details - SevereHead / nervous systemAutosomal recessive
Progressive Neuronopathy(PN)
Progressive neuronopathy is an inherited neurological disorder affecting the central nervous system, specifically the brain and spinal cord. In this condition, the nerve cells that transmit signals throughout the body gradually break down and lose their ability to function. Because these vital communication pathways degenerate, the brain can no longer properly control the dog's muscles and movements.
View details - SevereEyesAutosomal dominant
Progressive Retinal Atrophy (PRA), autosomal dominant, RHO-related(adPRA)
This is an inherited eye disease where a genetic defect in the rhodopsin (RHO) gene causes the light-sensitive cells in the retina to slowly break down and die. The retina is the layer at the back of the eye responsible for capturing light and sending visual signals to the brain. Because this degeneration is progressive, it leads to a gradual and permanent loss of vision.
View details - HighEyesAutosomal recessive
Progressive Retinal Atrophy (PRA), CCDC66-related(PRA-CCDC66)
This condition is an inherited eye disease caused by a genetic mutation in the CCDC66 gene, which leads to the gradual degeneration of the retina, the light-sensitive tissue at the back of the eye. Depending on the breed, it manifests as generalized progressive retinal atrophy (gPRA) in the Schapendoes or early-onset progressive retinal atrophy (EOPRA) in the Portuguese Water Dog. As these light-sensing cells break down, the eye permanently loses its ability to send visual signals to the brain.
View details - HighEyesAutosomal recessive
Progressive Retinal Atrophy (PRA), FAM161A-related(PRA-FAM161A)
This is an inherited eye disease affecting the retina, which is the light-sensitive tissue at the back of the eye. It is caused by mutations in the FAM161A gene that lead to the gradual breakdown and death of the cells responsible for vision. This genetic condition encompasses both the PRA3 variant found in Tibetan Spaniels and Tibetan Terriers, and the PRA6 variant found in English Shepherds.
View details - SevereEyesAutosomal recessive
Progressive Retinal Atrophy (PRA), GTPBP2-related(PRA-GTPBP2)
This is an inherited eye disease in Labrador Retrievers caused by a genetic mutation in the GTPBP2 gene. It leads to progressive retinal atrophy, which is the gradual breakdown of the light-sensitive cells at the back of the eye, known as the retina. As these cells degenerate, the dog's ability to process light and send visual signals to the brain is permanently lost.
View details - HighEyesAutosomal recessive
Progressive Retinal Atrophy (PRA), IFT122-related(PRA-IFT122)
This is an inherited eye disease where the retina, which is the light-sensitive tissue at the back of the eye, gradually degenerates. Specifically, the photoreceptor cells that detect light and color slowly die off. This progressive loss of cells eventually prevents the eye from sending visual signals to the brain.
View details - HighEyesAutosomal recessive
Progressive Retinal Atrophy (PRA), IMPG2-related(PRA4)
This is an inherited eye disease that causes the gradual breakdown of the retina, which is the light-sensitive tissue at the back of the eye. A genetic defect in the IMPG2 gene impairs the photoreceptor cells, which are the specialized cells responsible for detecting light and enabling vision. In the Lhasa Apso breed, this specific condition is commonly referred to as PRA4.
View details - HighEyesAutosomal recessive
Progressive Retinal Atrophy (PRA), JPH2-related(PRA-JPH2)
This is an inherited eye disease that causes the progressive degeneration of the retina, which is the light-sensitive layer of tissue at the back of the eye. Specifically linked to a mutation in the JPH2 gene, it causes the photoreceptor cells to gradually break down and die. This genetic variant is inherited in an autosomal recessive manner and is primarily identified in the Shih Tzu breed.
View details - HighEyesAutosomal recessive
Progressive Retinal Atrophy (PRA), NECAP1-related(PRA-NECAP1)
This genetic eye condition, also known as PRA5 or PRA-N, causes the light-sensitive cells of the retina at the back of the eye to slowly degenerate. Because of a defect in the NECAP1 gene, these cells cannot function properly and eventually die off. This gradual loss of retinal tissue leads to progressive and permanent blindness.
View details - HighEyesAutosomal recessive
Progressive Retinal Atrophy (PRA), Whippet(PRA)
This is an inherited eye disease in Whippets caused by a genetic mutation in the CABP4 gene, which affects the light-sensitive cells of the retina at the back of the eye. Over time, these cells gradually degenerate and lose their ability to send visual signals to the brain, eventually leading to complete blindness. Because it is an autosomal-recessive condition, a dog must inherit the mutated gene from both parents to develop the disease.
View details - HighEyesAutosomal recessive
Progressive Retinal Atrophy (SAG-related)(PRA-SAG)
This is an inherited eye disease where the retina, the light-sensitive layer at the back of the eye, gradually breaks down. It is caused by a genetic mutation in the SAG gene, which disrupts the normal function of proteins needed for vision. Over time, this defect leads to the progressive loss of the photoreceptor cells that detect light, eventually causing blindness.
View details - HighEyesX-linked
Progressive Retinal Atrophy, CACNA1F-related(PRA-CACNA1F)
This is an inherited eye disease affecting the retina, which is the light-sensitive layer at the back of the eye. A genetic defect in the calcium channels of the eye's photoreceptor cells prevents them from working correctly, causing them to slowly waste away. This progressive degeneration gradually destroys the cells responsible for both night and day vision.
View details - HighEyesAutosomal recessive
Progressive Retinal Atrophy, CNGA1-related(CNGA1-PRA)
This is an inherited eye disease affecting the retina, which is the light-sensitive layer at the back of the dog's eye. A genetic mutation in the CNGA1 gene causes the photoreceptor cells, which detect light, to slowly degenerate and die. Over time, this progressive loss of cells prevents the eye from sending clear visual signals to the brain.
View details - SevereEyesAutosomal recessive
Progressive Retinal Atrophy, Cone-rod dystrophy 1 (American Pit Bull Terrier)(PRA-crd1)
Progressive Retinal Atrophy (crd1) is an inherited eye disease that affects the retina, which is the light-sensitive layer at the back of the eye. In affected dogs, the specialized sensory cells responsible for both day vision (cones) and night vision (rods) degenerate prematurely and irreversibly. This gradual breakdown of cells eventually prevents the eye from sending visual signals to the brain.
View details - HighEyesAutosomal recessive
Progressive Retinal Atrophy, Early Onset (Spanish Water Dog)(PRA-EO)
Early Onset Progressive Retinal Atrophy, also known as EOPRA, is an inherited eye disease that causes the light-sensitive layer at the back of the eye, called the retina, to waste away prematurely. Because it is an autosomal-recessive condition, a dog must inherit the mutated gene from both parents to develop the disease. Over time, this cellular degeneration prevents the eye from sending clear visual signals to the brain, resulting in progressive and permanent vision loss.
View details - HighEyesAutosomal recessive
Progressive Retinal Atrophy, MERTK-related(PRA-MERTK)
This is an inherited eye disorder where the retina, which is the light-sensitive layer at the back of the eye, slowly degenerates due to a genetic mutation in the MERTK gene. This defect prevents the photoreceptor cells—the specialized cells that detect light—from recycling waste products properly, causing them to gradually die off. Over time, this progressive loss of cells leads to complete blindness.
View details
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