Progressive Retinal Atrophy (PRA), NECAP1-related(PRA-NECAP1)
Also known as: NECAP1-PRA · Progressive Retinal Atrophy NECAP1-related · NECAP1-assoziierte progressive Netzhautatrophie · NECAP1 progressive retinal atrophy · Progressive Retinal Atrophy Giant Schnauzer · …
Overview
What it is
This genetic eye condition, also known as PRA5 or PRA-N, causes the light-sensitive cells of the retina at the back of the eye to slowly degenerate. Because of a defect in the NECAP1 gene, these cells cannot function properly and eventually die off. This gradual loss of retinal tissue leads to progressive and permanent blindness.
How it presents
Owners typically first notice night blindness in early adulthood, where the dog becomes hesitant or clumsy in low-light conditions. Over time, this vision loss progresses during daylight hours, eventually leading to complete blindness.
Treatment
There is no cure to reverse or stop this genetic degeneration. Management focuses on supportive care and regular veterinary ophthalmology check-ups to monitor eye health, with lifetime costs ranging from 500 to 2000 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Progressive Retinal Atrophy (PRA), NECAP1-related?
This genetic eye condition, also known as PRA5 or PRA-N, causes the light-sensitive cells of the retina at the back of the eye to slowly degenerate. Because of a defect in the NECAP1 gene, these cells cannot function properly and eventually die off. This gradual loss of retinal tissue leads to progressive and permanent blindness.
How is Progressive Retinal Atrophy (PRA), NECAP1-related tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.