Progressive Retinal Atrophy, CNGA1-related(CNGA1-PRA)
Also known as: CNGA1-related progressive retinal atrophy · Progressive retinal atrophy CNGA1-type · Progressive Netzhautatrophie (CNGA1) · Shetland Sheepdog PRA CNGA1 · Retinal atrophy, progressive, CNGA1-related
Overview
What it is
This is an inherited eye disease affecting the retina, which is the light-sensitive layer at the back of the dog's eye. A genetic mutation in the CNGA1 gene causes the photoreceptor cells, which detect light, to slowly degenerate and die. Over time, this progressive loss of cells prevents the eye from sending clear visual signals to the brain.
How it presents
Owners typically first notice night blindness, where the dog hesitates or bumps into things in dim light, starting in young to middle adulthood. As the disease progresses, daytime vision also deteriorates, eventually leading to complete blindness.
Treatment
There is no cure for this condition, and the resulting vision loss is permanent. Lifelong management focuses on regular veterinary eye exams and adapting the home environment, with expected costs ranging from 300 to 1500 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Progressive Retinal Atrophy, CNGA1-related?
This is an inherited eye disease affecting the retina, which is the light-sensitive layer at the back of the dog's eye. A genetic mutation in the CNGA1 gene causes the photoreceptor cells, which detect light, to slowly degenerate and die. Over time, this progressive loss of cells prevents the eye from sending clear visual signals to the brain.
How is Progressive Retinal Atrophy, CNGA1-related tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.