Progressive Retinal Atrophy (PRA), CCDC66-related(PRA-CCDC66)
Also known as: Progressive Retinal Atrophy CCDC66-variant · CCDC66-PRA · Progressive retinal atrophy in Schapendoes · gPRA (CCDC66) · Progressive Netzhautatrophie (CCDC66) · …
Overview
What it is
This condition is an inherited eye disease caused by a genetic mutation in the CCDC66 gene, which leads to the gradual degeneration of the retina, the light-sensitive tissue at the back of the eye. Depending on the breed, it manifests as generalized progressive retinal atrophy (gPRA) in the Schapendoes or early-onset progressive retinal atrophy (EOPRA) in the Portuguese Water Dog. As these light-sensing cells break down, the eye permanently loses its ability to send visual signals to the brain.
How it presents
Owners typically first notice night blindness, where the dog hesitates or bumps into objects in dim light, which eventually progresses to complete daytime blindness. Depending on the specific breed form, these symptoms can begin to appear in early adulthood or even earlier.
Treatment
There is no cure for this condition, and it eventually leads to permanent blindness. Management focuses on supportive care and regular veterinary ophthalmologist check-ups, with lifetime costs typically ranging from 500 to 2000 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Progressive Retinal Atrophy (PRA), CCDC66-related?
This condition is an inherited eye disease caused by a genetic mutation in the CCDC66 gene, which leads to the gradual degeneration of the retina, the light-sensitive tissue at the back of the eye. Depending on the breed, it manifests as generalized progressive retinal atrophy (gPRA) in the Schapendoes or early-onset progressive retinal atrophy (EOPRA) in the Portuguese Water Dog. As these light-sensing cells break down, the eye permanently loses its ability to send visual signals to the brain.
How is Progressive Retinal Atrophy (PRA), CCDC66-related tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.