Primary Hyperoxaluria Type I (Oxalosis I)(PH1)
Also known as: Primary Hyperoxaluria Type 1 · Oxalosis I · AGXT deficiency · Primäre Hyperoxalurie Typ 1 · L-Alanine-Glyoxylate Aminotransferase Deficiency
Overview
What it is
Primary Hyperoxaluria Type I is a severe, inherited metabolic disorder affecting the liver and kidneys. Due to a missing liver enzyme, the body overproduces oxalic acid, which combines with calcium to form hard crystals in the kidneys. These crystals cause rapid, progressive damage to the urinary system and kidney tissues.
How it presents
Affected puppies typically show signs of sudden kidney failure within their first few weeks or months of life. Owners may notice vomiting, a loss of appetite, extreme weakness, and a significant decrease in urination.
Treatment
There is no cure for this condition, and treatment is limited to supportive care to keep the puppy comfortable. Due to the rapid progression of the disease, veterinary costs for diagnostics and short-term intensive care typically range from 500 to 2500 EUR.
How it's tested
Primäre Hyperoxalurie Typ I (PH1) DNA-Test(PH1)
Primary testDNA testEin Gentest, der die ursächliche Mutation im AGXT-Gen nachweist, um betroffene Hunde und Anlageträger der primären Hyperoxalurie Typ I zu identifizieren.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Primary Hyperoxaluria Type I (Oxalosis I)?
Primary Hyperoxaluria Type I is a severe, inherited metabolic disorder affecting the liver and kidneys. Due to a missing liver enzyme, the body overproduces oxalic acid, which combines with calcium to form hard crystals in the kidneys. These crystals cause rapid, progressive damage to the urinary system and kidney tissues.
How is Primary Hyperoxaluria Type I (Oxalosis I) tested?
Tests currently in our database: Primäre Hyperoxalurie Typ I (PH1) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.