Progressive Retinal Atrophy, CACNA1F-related(PRA-CACNA1F)
Also known as: CACNA1F-PRA · X-linked Progressive Retinal Atrophy · CACNA1F-related PRA · X-gebundene progressive Retinaatrophie · Retinal atrophy, progressive, CACNA1F-related
Overview
What it is
This is an inherited eye disease affecting the retina, which is the light-sensitive layer at the back of the eye. A genetic defect in the calcium channels of the eye's photoreceptor cells prevents them from working correctly, causing them to slowly waste away. This progressive degeneration gradually destroys the cells responsible for both night and day vision.
How it presents
Affected dogs typically show signs of night blindness in early adulthood, such as hesitating in the dark or bumping into furniture. Over time, this progresses to a loss of daytime vision and eventually leads to complete blindness.
Treatment
While this genetic condition is currently incurable, it is entirely painless. Lifelong management involves regular veterinary eye exams and supportive care, with expected costs ranging from 500 to 2000 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Progressive Retinal Atrophy, CACNA1F-related?
This is an inherited eye disease affecting the retina, which is the light-sensitive layer at the back of the eye. A genetic defect in the calcium channels of the eye's photoreceptor cells prevents them from working correctly, causing them to slowly waste away. This progressive degeneration gradually destroys the cells responsible for both night and day vision.
How is Progressive Retinal Atrophy, CACNA1F-related tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.