Progressive Retinal Atrophy (SAG-related)(PRA-SAG)
Also known as: SAG-PRA · Basenji PRA · Progressive Retinal Atrophy Basenji-type · S-antigen progressive retinal atrophy · Arrestin-related PRA · …
Overview
What it is
This is an inherited eye disease where the retina, the light-sensitive layer at the back of the eye, gradually breaks down. It is caused by a genetic mutation in the SAG gene, which disrupts the normal function of proteins needed for vision. Over time, this defect leads to the progressive loss of the photoreceptor cells that detect light, eventually causing blindness.
How it presents
Owners typically first notice night blindness, where the dog hesitates or bumps into objects in dim light, starting around five years of age. As the disease advances, daytime vision also deteriorates, eventually leading to complete blindness.
Treatment
There is no cure for this condition, but it progresses painlessly. Lifetime management costs, including diagnostic exams by a veterinary ophthalmologist and supportive care, typically range from 500 to 2000 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Progressive Retinal Atrophy (SAG-related)?
This is an inherited eye disease where the retina, the light-sensitive layer at the back of the eye, gradually breaks down. It is caused by a genetic mutation in the SAG gene, which disrupts the normal function of proteins needed for vision. Over time, this defect leads to the progressive loss of the photoreceptor cells that detect light, eventually causing blindness.
How is Progressive Retinal Atrophy (SAG-related) tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.