Progressive Retinal Atrophy (PRA), FAM161A-related(PRA-FAM161A)
Also known as: FAM161A-PRA · Progressive Retinal Atrophy FAM161A-related · Tibetan Spaniel PRA · FAM161A-associated progressive retinal atrophy · Retinal atrophy, progressive, FAM161A-related · …
Overview
What it is
This is an inherited eye disease affecting the retina, which is the light-sensitive tissue at the back of the eye. It is caused by mutations in the FAM161A gene that lead to the gradual breakdown and death of the cells responsible for vision. This genetic condition encompasses both the PRA3 variant found in Tibetan Spaniels and Tibetan Terriers, and the PRA6 variant found in English Shepherds.
How it presents
Owners typically first notice night blindness, where the dog hesitates or bumps into objects in dim light, starting in early to middle adulthood. As the disease progresses, daytime vision also deteriorates, eventually leading to complete blindness.
Treatment
There is no cure for this condition, and the resulting vision loss is permanent. Supportive care, regular veterinary eye exams, and home safety adjustments are recommended, with lifetime management costs ranging from 500 to 2,500 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Progressive Retinal Atrophy (PRA), FAM161A-related?
This is an inherited eye disease affecting the retina, which is the light-sensitive tissue at the back of the eye. It is caused by mutations in the FAM161A gene that lead to the gradual breakdown and death of the cells responsible for vision. This genetic condition encompasses both the PRA3 variant found in Tibetan Spaniels and Tibetan Terriers, and the PRA6 variant found in English Shepherds.
How is Progressive Retinal Atrophy (PRA), FAM161A-related tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.