Progressive degenerative myeloencephalopathy, PNPLA8-related
Also known as: PNPLA8-associated neurodegeneration · Progressive degenerative myeloencephalopathy · PNPLA8-related myeloencephalopathy · PNPLA8-Enzephalopathie · Neurodegenerative disease PNPLA8-related · …
Overview
What it is
This is a severe inherited disease of the central nervous system, specifically affecting the brain and spinal cord. It is caused by a genetic mutation in the PNPLA8 gene, which leads to the progressive breakdown and loss of nerve tissue. As this nerve tissue degenerates, the brain's ability to communicate with the rest of the body is gradually lost.
How it presents
Symptoms typically appear within the first year of life. Owners will first notice coordination issues, tremors, and weakness in the hind legs, which steadily worsens over time and eventually leads to paralysis.
Treatment
There is no cure for this condition, and care is focused on keeping the dog comfortable. Managing the symptoms and diagnostic testing typically costs between 500 and 2,500 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Progressive degenerative myeloencephalopathy, PNPLA8-related?
This is a severe inherited disease of the central nervous system, specifically affecting the brain and spinal cord. It is caused by a genetic mutation in the PNPLA8 gene, which leads to the progressive breakdown and loss of nerve tissue. As this nerve tissue degenerates, the brain's ability to communicate with the rest of the body is gradually lost.
How is Progressive degenerative myeloencephalopathy, PNPLA8-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.