Progressive Retinal Atrophy (PRA), IMPG2-related(PRA4)
Also known as: IMPG2-PRA · Progressive Retinal Atrophy IMPG2-type · IMPG2-related PRA · Progressive Retinaatrophie IMPG2 · IMPG2-associated progressive retinal atrophy · …
Overview
What it is
This is an inherited eye disease that causes the gradual breakdown of the retina, which is the light-sensitive tissue at the back of the eye. A genetic defect in the IMPG2 gene impairs the photoreceptor cells, which are the specialized cells responsible for detecting light and enabling vision. In the Lhasa Apso breed, this specific condition is commonly referred to as PRA4.
How it presents
Affected dogs typically begin showing signs of night blindness, such as bumping into objects or hesitating in dim light, during early to mid-adulthood. As the disease progresses, daytime vision also declines, eventually resulting in complete blindness.
Treatment
There is no cure for this condition, and the resulting blindness is permanent. Managing the disease involves lifelong supportive care and environmental adjustments to keep the dog safe, with expected veterinary and management costs ranging from 500 to 2000 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Progressive Retinal Atrophy (PRA), IMPG2-related?
This is an inherited eye disease that causes the gradual breakdown of the retina, which is the light-sensitive tissue at the back of the eye. A genetic defect in the IMPG2 gene impairs the photoreceptor cells, which are the specialized cells responsible for detecting light and enabling vision. In the Lhasa Apso breed, this specific condition is commonly referred to as PRA4.
How is Progressive Retinal Atrophy (PRA), IMPG2-related tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.