Progressive Retinal Atrophy (PRA), GTPBP2-related(PRA-GTPBP2)
Also known as: GTPBP2-associated progressive retinal atrophy · GTPBP2-PRA · Progressive retinal atrophy GTPBP2-related · GTPBP2-related PRA · Progressive Retinaatrophie GTPBP2-assoziiert · …
Overview
What it is
This is an inherited eye disease in Labrador Retrievers caused by a genetic mutation in the GTPBP2 gene. It leads to progressive retinal atrophy, which is the gradual breakdown of the light-sensitive cells at the back of the eye, known as the retina. As these cells degenerate, the dog's ability to process light and send visual signals to the brain is permanently lost.
How it presents
Owners will typically first notice night blindness, where the dog hesitates or bumps into objects in dim light. This condition eventually progresses to total vision loss during the day, with symptoms usually beginning at a young age.
Treatment
There is no cure for this condition, and the resulting blindness is permanent. Veterinary care focuses on diagnostic confirmation and helping the dog safely adapt to vision loss, with lifetime costs typically ranging from 300 to 1500 EUR.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Progressive Retinal Atrophy (PRA), GTPBP2-related?
This is an inherited eye disease in Labrador Retrievers caused by a genetic mutation in the GTPBP2 gene. It leads to progressive retinal atrophy, which is the gradual breakdown of the light-sensitive cells at the back of the eye, known as the retina. As these cells degenerate, the dog's ability to process light and send visual signals to the brain is permanently lost.
How is Progressive Retinal Atrophy (PRA), GTPBP2-related tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.