Progressive Retinal Atrophy (PRA), autosomal dominant, RHO-related(adPRA)
Also known as: Autosomal dominant progressive retinal atrophy · RHO-PRA · Rhodopsin-related progressive retinal atrophy · RHO-adPRA · AD-PRA · …
Overview
What it is
This is an inherited eye disease where a genetic defect in the rhodopsin (RHO) gene causes the light-sensitive cells in the retina to slowly break down and die. The retina is the layer at the back of the eye responsible for capturing light and sending visual signals to the brain. Because this degeneration is progressive, it leads to a gradual and permanent loss of vision.
How it presents
Owners typically first notice signs of night blindness, such as hesitation or bumping into objects in the dark, during early to middle adulthood. Over time, this vision loss progresses to complete blindness in both daylight and low light.
Treatment
There is no cure for this condition, but it is painless for the dog. Lifelong management focuses on regular veterinary eye exams and supportive care, with typical costs ranging from 500 to 2,500 EUR over the dog's lifetime.
How it's tested
ECVO Augenuntersuchung (DOK)(ECVO-DOK)
Primary testEye examAugenuntersuchung durch ECVO-zertifizierten Augentierarzt (Dortmunder Kreis). Erkennt PRA, Katarakt, Entropium, CEA, MPP, RD u.a.
Issuing body: ECVO
Result scheme: Eye-ECVO
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Progressive Retinal Atrophy (PRA), autosomal dominant, RHO-related?
This is an inherited eye disease where a genetic defect in the rhodopsin (RHO) gene causes the light-sensitive cells in the retina to slowly break down and die. The retina is the layer at the back of the eye responsible for capturing light and sending visual signals to the brain. Because this degeneration is progressive, it leads to a gradual and permanent loss of vision.
How is Progressive Retinal Atrophy (PRA), autosomal dominant, RHO-related tested?
Tests currently in our database: ECVO Augenuntersuchung (DOK), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.