Protein-losing enteropathy(PLE)
Overview
What it is
Protein-losing enteropathy (PLE) is a severe condition affecting the digestive system where the lining of the intestines becomes damaged or inflamed. This damage prevents the intestines from properly absorbing nutrients, causing vital proteins to leak from the bloodstream into the digestive tract. Because these proteins are lost instead of recycled, the body struggles to maintain normal fluid balance and muscle mass.
How it presents
Owners typically notice chronic diarrhea, vomiting, weight loss, and swelling in the abdomen or legs due to fluid buildup. These symptoms most commonly begin to appear in young to middle-aged dogs.
Treatment
While PLE is not curable, it can be managed long-term with a strict, lifelong ultra-low-fat diet and daily medications to control inflammation. Ongoing veterinary care and dietary management are required, with lifetime treatment costs typically ranging from €3,000 to €12,000.
How it's tested
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Protein-losing enteropathy?
Protein-losing enteropathy (PLE) is a severe condition affecting the digestive system where the lining of the intestines becomes damaged or inflamed. This damage prevents the intestines from properly absorbing nutrients, causing vital proteins to leak from the bloodstream into the digestive tract. Because these proteins are lost instead of recycled, the body struggles to maintain normal fluid balance and muscle mass.
How is Protein-losing enteropathy tested?
Various clinical and genetic tests are used depending on the breed and presentation.
Which breeds are most affected?
Most commonly affected: Irish Soft Coated Wheaten Terrier.