Mucopolysaccharidosis VI(MPS VI)
Also known as: Mucopolysaccharidosis Type VI · Maroteaux-Lamy syndrome · Arylsulfatase B deficiency · Maroteaux-Lamy-Syndrom
Overview
What it is
Mucopolysaccharidosis VI (MPS VI) is an inherited metabolic disease where the body lacks a specific enzyme called arylsulfatase B. Without this enzyme, complex sugar molecules called glycosaminoglycans cannot be broken down and instead build up to harmful levels in the body's tissues. This accumulation primarily damages the skeletal system, joints, and eyes.
How it presents
Symptoms usually become visible within the first few months of life. Owners may notice unusually short stature (dwarfism), skeletal deformities, cloudy eyes, joint pain, and a progressive loss of mobility or paralysis.
Treatment
There is no cure for this progressive condition, so treatment focuses entirely on managing pain and maintaining comfort. Lifelong supportive care is required, with estimated veterinary costs ranging from €2,000 to €7,000.
How it's tested
Mucopolysaccharidose Typ VI (MPS VI) Gentest(MPS VI)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation im ARSB-Gen, welche zum Mangel des Enzyms Arylsulfatase B führt.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Mucopolysaccharidosis VI?
Mucopolysaccharidosis VI (MPS VI) is an inherited metabolic disease where the body lacks a specific enzyme called arylsulfatase B. Without this enzyme, complex sugar molecules called glycosaminoglycans cannot be broken down and instead build up to harmful levels in the body's tissues. This accumulation primarily damages the skeletal system, joints, and eyes.
How is Mucopolysaccharidosis VI tested?
Tests currently in our database: Mucopolysaccharidose Typ VI (MPS VI) Gentest.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.