Mucopolysaccharidosis II(MPS II)
Also known as: Mucopolysaccharidose Typ II · Hunter Syndrome · Iduronate-2-Sulfatase Deficiency · Lysosomale Speicherkrankheit Typ II
Overview
What it is
Mucopolysaccharidosis II (MPS II) is a severe, inherited metabolic disorder caused by a deficiency in an enzyme needed to break down complex sugar molecules. Without this enzyme, these sugars build up inside cells, causing progressive damage to multiple organ systems, including the skeleton and the nervous system. This condition is inherited in an X-linked manner, meaning it primarily affects male dogs.
How it presents
Symptoms typically become noticeable in early puppyhood. Owners may observe stunted growth, skeletal deformities, cloudy eyes, and progressive difficulty walking or coordinating movements.
Treatment
There is no cure for this progressive disease, and treatment is limited to lifelong supportive care to manage pain and maintain comfort. Supportive veterinary care typically costs between 1,000 and 5,000 EUR.
How it's tested
Mucopolysaccharidose Typ II DNA-Test(MPS II)
Primary testDNA testDer DNA-Test analysiert das IDS-Gen auf die ursächliche Mutation für Mucopolysaccharidose Typ II, um betroffene Hunde und heterozygote Träger sicher zu identifizieren.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Mucopolysaccharidosis II?
Mucopolysaccharidosis II (MPS II) is a severe, inherited metabolic disorder caused by a deficiency in an enzyme needed to break down complex sugar molecules. Without this enzyme, these sugars build up inside cells, causing progressive damage to multiple organ systems, including the skeleton and the nervous system. This condition is inherited in an X-linked manner, meaning it primarily affects male dogs.
How is Mucopolysaccharidosis II tested?
Tests currently in our database: Mucopolysaccharidose Typ II DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.