Mucopolysaccharidosis I(MPS I)
Also known as: Mucopolysaccharidosis Type I · Hurler syndrome · alpha-L-iduronidase deficiency · IDUA deficiency · Hurler-Syndrom beim Hund · …
Overview
What it is
Mucopolysaccharidosis I (MPS I) is an inherited metabolic disorder where the body lacks a specific enzyme needed to break down complex sugar molecules. Without this enzyme, these sugars build up inside cells, causing progressive damage to multiple organ systems, including the bones, joints, and central nervous system.
How it presents
Symptoms typically become noticeable in early puppyhood and include stunted growth, joint stiffness, clouding of the eyes, and progressive difficulty moving.
Treatment
There is no cure for this condition, and management is limited to lifelong supportive care to maintain comfort. Ongoing veterinary support and palliative care typically cost between €1,500 and €5,000.
How it's tested
Mucopolysaccharidose Typ I (MPS I) DNA-Test(MPS I)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation im IDUA-Gen, die für den Mangel des Enzyms Alpha-L-Iduronidase verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Mucopolysaccharidosis I?
Mucopolysaccharidosis I (MPS I) is an inherited metabolic disorder where the body lacks a specific enzyme needed to break down complex sugar molecules. Without this enzyme, these sugars build up inside cells, causing progressive damage to multiple organ systems, including the bones, joints, and central nervous system.
How is Mucopolysaccharidosis I tested?
Tests currently in our database: Mucopolysaccharidose Typ I (MPS I) DNA-Test.
Which breeds are most affected?
Most commonly affected: Plott Hound.