Copper toxicosis, COMMD1-related(CT)
Also known as: Bedlington Terrier Copper Toxicosis · COMMD1-associated copper storage disease · Kupferspeicherkrankheit des Bedlington Terriers · Copper storage hepatopathy · COMMD1 deficiency
Overview
What it is
This is an inherited genetic disorder where a mutation in the COMMD1 gene prevents the liver from properly excreting copper. As a result, copper builds up to toxic levels in the liver cells, causing progressive damage, inflammation (chronic hepatitis), and scarring of the liver tissue.
How it presents
Owners typically notice symptoms like vomiting, weight loss, sluggishness, and a yellowing of the skin or eyes (jaundice) starting between 2 and 4 years of age. Without intervention, the disease can progress to severe liver failure.
Treatment
While the condition cannot be cured, it is manageable with lifelong treatment including a low-copper diet, medications to bind copper, and zinc therapy. Managing this chronic condition requires regular veterinary monitoring and costs between 3,000 and 10,000 EUR.
How it's tested
Kupfertoxikose (COMMD1) DNA-Test(CT)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der Mutation im COMMD1-Gen, die zu einer abnormalen Kupferakkumulation in der Leber führt.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Copper toxicosis, COMMD1-related?
This is an inherited genetic disorder where a mutation in the COMMD1 gene prevents the liver from properly excreting copper. As a result, copper builds up to toxic levels in the liver cells, causing progressive damage, inflammation (chronic hepatitis), and scarring of the liver tissue.
How is Copper toxicosis, COMMD1-related tested?
Tests currently in our database: Kupfertoxikose (COMMD1) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.