Congenital muscular dystrophy, LAMA2-related(CMD)
Also known as: LAMA2-CMD · Merosin-deficient congenital muscular dystrophy · MDC1A · Kongenitale Muskeldystrophie Typ 1A · LAMA2-assoziierte Muskeldystrophie
Overview
What it is
This is an inherited muscle disorder caused by a deficiency of laminin-alpha-2, a vital protein that acts as a structural anchor to keep muscle fibers stable. Without this protein, the skeletal muscles progressively break down and weaken over time. This leads to a gradual loss of mobility and strength across the dog's entire muscular system.
How it presents
Symptoms typically appear in early puppyhood, with owners noticing severe muscle weakness, stiffness, and difficulty walking. Over time, there is a visible loss of muscle mass as the condition progresses.
Treatment
There is no cure for this condition, meaning treatment is lifelong and focused on supportive care, such as physical therapy, to maintain comfort. Managing this progressive disease typically costs between 1,500 and 6,000 EUR.
How it's tested
LAMA2-kongenitale Muskeldystrophie Gentest(LAMA2-CMD)
Primary testDNA testEin Gentest, der die ursächliche Mutation im LAMA2-Gen nachweist, um betroffene Hunde und symptomfreie Anlageträger sicher zu identifizieren.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Congenital muscular dystrophy, LAMA2-related?
This is an inherited muscle disorder caused by a deficiency of laminin-alpha-2, a vital protein that acts as a structural anchor to keep muscle fibers stable. Without this protein, the skeletal muscles progressively break down and weaken over time. This leads to a gradual loss of mobility and strength across the dog's entire muscular system.
How is Congenital muscular dystrophy, LAMA2-related tested?
Tests currently in our database: LAMA2-kongenitale Muskeldystrophie Gentest.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.