Afibrinogenemia or hypofibrinogenemia(FI)
Also known as: Factor I deficiency · Congenital afibrinogenemia · Fibrinogen deficiency · Faktor-I-Mangel · Hypofibrinogenämie des Hundes · …
Overview
What it is
This is an inherited blood clotting disorder affecting the cardiovascular system, specifically how the blood seals wounds. It is caused by a deficiency or complete lack of fibrinogen, which is a crucial protein needed for blood to clot. Without enough of this protein, the body cannot form stable clots to stop bleeding.
How it presents
Symptoms typically appear during puppyhood, often starting when a young dog is teething. Owners may notice spontaneous bruising, bleeding gums, or unusually heavy bleeding from minor cuts and scratches.
Treatment
The condition is incurable, but emergency bleeding episodes can be managed with blood or plasma transfusions. This lifelong management typically costs between 1,500 and 8,000 EUR depending on the frequency of bleeding episodes.
How it's tested
Faktor-I-Defizienz (Hypofibrinogenämie) DNA-Test(FI)
Primary testDNA testEin Gentest zum Nachweis von Mutationen im FGA-Gen, die zu einem Mangel an funktionellem Fibrinogen (Gerinnungsfaktor I) führen.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Afibrinogenemia or hypofibrinogenemia?
This is an inherited blood clotting disorder affecting the cardiovascular system, specifically how the blood seals wounds. It is caused by a deficiency or complete lack of fibrinogen, which is a crucial protein needed for blood to clot. Without enough of this protein, the body cannot form stable clots to stop bleeding.
How is Afibrinogenemia or hypofibrinogenemia tested?
Tests currently in our database: Faktor-I-Defizienz (Hypofibrinogenämie) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.