Xanthinuria, type II
Also known as: Xanthine urolithiasis · Xanthinuria Type 2 · MOCOS deficiency · Xanthinurie Typ II · Hereditary xanthinuria type II
Overview
What it is
Xanthinuria type II is an inherited metabolic disorder affecting the urinary system, where a missing enzyme prevents the body from properly breaking down xanthine, which is a natural byproduct of protein metabolism. Because the body cannot process this compound, xanthine builds up in the kidneys and bladder. Over time, this accumulation can lead to the formation of painful urinary stones.
How it presents
Owners typically notice symptoms in young to middle-aged dogs, including blood in the urine, straining or pain during urination, and frequent attempts to urinate. If a stone completely blocks the flow of urine, it can quickly become a medical emergency.
Treatment
While the underlying defect is lifelong and incurable, it can be managed with a strict low-purine diet and high fluid intake. If urinary stones develop, surgical removal is often necessary, with overall treatment and management costs ranging from 1,000 to 6,000 EUR.
How it's tested
Xanthinurie Typ II DNA-Test(Xanth-II)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der ursächlichen Mutation im MOCOS-Gen, die zu Xanthinurie Typ II führt.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Xanthinuria, type II?
Xanthinuria type II is an inherited metabolic disorder affecting the urinary system, where a missing enzyme prevents the body from properly breaking down xanthine, which is a natural byproduct of protein metabolism. Because the body cannot process this compound, xanthine builds up in the kidneys and bladder. Over time, this accumulation can lead to the formation of painful urinary stones.
How is Xanthinuria, type II tested?
Tests currently in our database: Xanthinurie Typ II DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.