Xanthinuria, type I
Also known as: Xanthine dehydrogenase deficiency · Xanthine urolithiasis · Xanthinuria Type 1 · Xanthinurie Typ I · Hereditäre Xanthinurie
Overview
What it is
This is an inherited metabolic disorder where a missing enzyme prevents the body from properly breaking down purines, which are natural compounds found in food. This enzyme deficiency causes a byproduct called xanthine to build up in the kidneys and bladder, where it forms painful urinary stones. This primary metabolic defect directly impacts the health of the urinary system.
How it presents
Owners typically notice signs within the first few years of a dog's life, such as blood in the urine, straining or pain during urination, and recurrent urinary tract infections. If a stone blocks the urinary tract, it can lead to a life-threatening inability to urinate.
Treatment
The condition requires lifelong management with a specialized low-purine diet and increased fluid intake, though existing stones may require surgical removal. The estimated cost for diagnosis, potential surgery, and ongoing dietary management ranges from 1,500 to 6,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Xanthinuria, type I?
This is an inherited metabolic disorder where a missing enzyme prevents the body from properly breaking down purines, which are natural compounds found in food. This enzyme deficiency causes a byproduct called xanthine to build up in the kidneys and bladder, where it forms painful urinary stones. This primary metabolic defect directly impacts the health of the urinary system.
How is Xanthinuria, type I tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.