X-linked Progressive Retinal Atrophy(XLPRA1)
Also known as: X-linked PRA · XLPRA · X-chromosomale PRA · RPGR-associated PRA
Overview
What it is
X-linked Progressive Retinal Atrophy is an inherited eye disease that causes the gradual breakdown of the retina, which is the light-sensitive tissue at the back of the eye. This degeneration affects the photoreceptor cells, which are the specialized cells responsible for detecting light. Over time, the loss of these cells leads to complete blindness.
How it presents
Symptoms typically begin between 2 and 5 years of age, starting with night blindness where the dog may hesitate in low light or bump into objects. Over time, this progresses to a noticeable loss of daytime vision.
Treatment
This condition is currently incurable, and management is focused on supportive care and regular veterinary eye exams. Lifelong monitoring and lifestyle adjustments to support the dog's vision loss typically cost between 500 and 2,500 EUR.
How it's tested
XLPRA1 DNA-Test(XLPRA1)
Primary testDNA testEin Gentest zum Nachweis der Mutation im RPGR-Gen, die für die X-chromosomale progressive Retinaatrophie (XLPRA1) bei Siberian Huskies und Samojeden verantwortlich ist.
Issuing body: Optigen
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is X-linked Progressive Retinal Atrophy?
X-linked Progressive Retinal Atrophy is an inherited eye disease that causes the gradual breakdown of the retina, which is the light-sensitive tissue at the back of the eye. This degeneration affects the photoreceptor cells, which are the specialized cells responsible for detecting light. Over time, the loss of these cells leads to complete blindness.
How is X-linked Progressive Retinal Atrophy tested?
Tests currently in our database: XLPRA1 DNA-Test.
Which breeds are most affected?
Most commonly affected: Alaskan Husky.