Polyneuropathy, NDRG1-related(AMPN)
Also known as: Alaskan Malamute Polyneuropathy · Greyhound Polyneuropathy · GHPN · NDRG1-associated polyneuropathy · NDRG1-PN · …
Overview
What it is
This is an inherited disorder of the peripheral nervous system where the protective outer coating of the nerves, known as the myelin sheath, gradually breaks down. Without this protective layer, the electrical signals traveling between the brain and the muscles are disrupted. This leads to a progressive loss of muscle control and coordination throughout the dog's body.
How it presents
Symptoms typically appear before two years of age, starting with an abnormal gait, hind limb weakness, and muscle wasting. As the disease progresses, owners may also notice hoarseness, changes in barking, and breathing difficulties due to paralysis of the voice box.
Treatment
There is no cure for this progressive condition, and treatment is limited to lifelong supportive care to manage symptoms. Supportive therapy typically costs between 1,000 and 4,000 EUR, though severe loss of quality of life often leads to a decision for early euthanasia.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Greyhound-Neuropathie DNA-Test(GN)
Primary testDNA testDer DNA-Test auf Greyhound-Neuropathie identifiziert die ursächliche Mutation im NDRG1-Gen, um betroffene Hunde, Träger und mutationsfreie Tiere zu identifizieren.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Polyneuropathy, NDRG1-related?
This is an inherited disorder of the peripheral nervous system where the protective outer coating of the nerves, known as the myelin sheath, gradually breaks down. Without this protective layer, the electrical signals traveling between the brain and the muscles are disrupted. This leads to a progressive loss of muscle control and coordination throughout the dog's body.
How is Polyneuropathy, NDRG1-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Greyhound-Neuropathie DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Alaskan Malamute, Greyhound, Spanish Galgo.