Neonatal Encephalopathy with Seizures(NEWS)
Also known as: Neonatal Encephalopathy · Neonatale Enzephalopathie · NEWS-Poodle · ATF2-related encephalopathy · ATF2-related neonatal encephalopathy · …
Overview
What it is
This is a severe, inherited brain disorder that affects newborn puppies, caused by an autosomal-recessive genetic mutation. It leads to abnormal development and degeneration of the central nervous system, which controls the body's movements and mental functions. Because it is inherited recessively, a puppy must inherit the mutated gene from both parents to be affected.
How it presents
Symptoms typically appear shortly after birth, often within the first few days of life. Owners will notice extreme weakness, severe muscle tremors, a lack of coordination, and seizures. Affected puppies fail to thrive and rarely survive past seven weeks of age.
Treatment
This condition is incurable and always fatal, with treatment limited to supportive care or humane euthanasia to prevent suffering. Veterinary costs for diagnosis and compassionate end-of-life care typically range from 150 to 500 EUR.
How it's tested
Neonatale Enzephalopathie (NEWS) DNA-Test(NEWS)
Primary testDNA testEin DNA-Test zum Nachweis der Mutation im ATF2-Gen, die für die neonatale Enzephalopathie mit Laktatazidose verantwortlich ist, um Träger und betroffene Hunde zu identifizieren.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Neonatal Encephalopathy with Seizures?
This is a severe, inherited brain disorder that affects newborn puppies, caused by an autosomal-recessive genetic mutation. It leads to abnormal development and degeneration of the central nervous system, which controls the body's movements and mental functions. Because it is inherited recessively, a puppy must inherit the mutated gene from both parents to be affected.
How is Neonatal Encephalopathy with Seizures tested?
Tests currently in our database: Neonatale Enzephalopathie (NEWS) DNA-Test, Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Poodle, Standard Poodle, Toy Poodle, Aussiedoodle, Bernedoodle, Goldendoodle, Maltipoo.