Neuronal Ceroid Lipofuscinosis(NCL)
Also known as: Batten Disease · Ceroid-Lipofuszinose · NCL-Erkrankung · Lipofuszinose · Neuronale Ceroid-Lipofuszinose · …
Overview
What it is
Neuronal Ceroid Lipofuscinosis (NCL) is an inherited metabolic disorder that affects the nervous system. It occurs when nerve cells in the brain and eyes are unable to properly recycle cellular waste, leading to a harmful buildup of these materials that permanently damages the tissues.
How it presents
Symptoms typically begin to show between 1 and 3 years of age. Owners may notice behavioral changes, a gradual loss of vision, difficulty coordinating movements, and seizures.
Treatment
There is no cure for this fatal condition, so treatment is limited to supportive care to keep the dog comfortable. Managing symptoms and providing palliative care typically costs between 1,000 and 4,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Neuronale Ceroid-Lipofuszinose (NCL) DNA-Test(NCL)
Primary testDNA testEin Gentest mittels PCR identifiziert die spezifische Mutation im CLN-Gen, die fuer die neuronale Ceroid-Lipofuszinose verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
11 of 11 breeds
Mandatory testAlpine DachsbrackeMandated by Verein Dachsbracke e.V. (VDH)
Mandatory testAmerican Bully
Mandatory testAustralian Cattle Dog
Mandatory testTibetan Spaniel
Mandatory testTibetan TerrierMandated by KTR (VDH), CTA (VDH), ILT (VDH)
RecommendedChinese Crested Dog
RecommendedEnglish Setter
RecommendedMiniature Dachshund
RecommendedMiniature Long-haired Dachshund
RecommendedMiniature Smooth-haired Dachshund
OptionalMaremma Sheepdog
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Neuronal Ceroid Lipofuscinosis?
Neuronal Ceroid Lipofuscinosis (NCL) is an inherited metabolic disorder that affects the nervous system. It occurs when nerve cells in the brain and eyes are unable to properly recycle cellular waste, leading to a harmful buildup of these materials that permanently damages the tissues.
How is Neuronal Ceroid Lipofuscinosis tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Neuronale Ceroid-Lipofuszinose (NCL) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Alpine Dachsbracke, American Bully, Australian Cattle Dog, Tibetan Spaniel, Tibetan Terrier, Chinese Crested Dog, English Setter, Miniature Dachshund.