Paw pad hyperkeratosis, GJB6-related(HFH)
Also known as: Hereditary Footpad Hyperkeratosis · GJB6-related footpad hyperkeratosis · Familiäre Pfotenballen-Hyperkeratose · Digitale Hyperkeratose
Overview
What it is
This genetic condition is caused by a mutation in the GJB6 gene, which affects the skin on a dog's paws. It leads to an overproduction of keratin, the tough protective protein that makes up the outer layer of the paw pads, causing them to become abnormally thick and hard.
How it presents
Owners will typically notice symptoms within the first year of life as the paw pads become severely thickened, cracked, and develop hard, horn-like growths. These changes can cause discomfort, pain, and visible limping when the dog walks.
Treatment
The condition is incurable and requires lifelong management, including regular trimming of the excess keratin and applying moisturizing ointments. Ongoing care is estimated to cost between 1,000 and 4,000 EUR.
How it's tested
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Paw pad hyperkeratosis, GJB6-related?
This genetic condition is caused by a mutation in the GJB6 gene, which affects the skin on a dog's paws. It leads to an overproduction of keratin, the tough protective protein that makes up the outer layer of the paw pads, causing them to become abnormally thick and hard.
How is Paw pad hyperkeratosis, GJB6-related tested?
Various clinical and genetic tests are used depending on the breed and presentation.
Which breeds are most affected?
Most commonly affected: Kromfohrländer.