Ehlers-Danlos syndrome (Cutaneous asthenia)(EDS)
Also known as: Ehlers-Danlos-Syndrom · Hautasthenie · Rubber skin disease · Kollagendysplasie · Cutaneous asthenia · …
Overview
What it is
Ehlers-Danlos syndrome, also known as cutaneous asthenia, is an inherited connective tissue disorder that affects the skin and joints. It is caused by a genetic defect in collagen, which is the primary structural protein that provides strength and elasticity to tissues. Because of this defect, the skin lacks its normal structural integrity, making it unusually fragile, thin, and loose.
How it presents
Owners typically notice symptoms starting in puppyhood, characterized by extremely stretchy, loose skin folds that tear easily during normal play or grooming. These minor injuries often lead to deep, slow-healing wounds and prominent scarring, and some dogs may also show unusually loose or flexible joints.
Treatment
There is no cure for this lifelong condition, and management focuses on preventing injuries through a protected environment and protective clothing. Ongoing veterinary care is required to surgically repair skin tears, with lifetime costs typically ranging from 1,500 to 8,000 EUR.
How it's tested
Ehlers-Danlos-Syndrom (EDS) DNA-Test(EDS)
Primary testDNA testDer DNA-Test identifiziert spezifische Mutationen in Kollagen-Genen (wie COL5A1 oder COL5A2), die für die fehlerhafte Struktur des Bindegewebes verantwortlich sind.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
Klassisches Ehlers-Danlos-Syndrom (cEDS) DNA-Test(cEDS (COL5A1))
Primary testDNA testDer Gentest identifiziert die spezifische Mutation im COL5A1-Gen, welche für das klassische Ehlers-Danlos-Syndrom verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Ehlers-Danlos syndrome (Cutaneous asthenia)?
Ehlers-Danlos syndrome, also known as cutaneous asthenia, is an inherited connective tissue disorder that affects the skin and joints. It is caused by a genetic defect in collagen, which is the primary structural protein that provides strength and elasticity to tissues. Because of this defect, the skin lacks its normal structural integrity, making it unusually fragile, thin, and loose.
How is Ehlers-Danlos syndrome (Cutaneous asthenia) tested?
Tests currently in our database: Ehlers-Danlos-Syndrom (EDS) DNA-Test, Klassisches Ehlers-Danlos-Syndrom (cEDS) DNA-Test.
Which breeds are most affected?
Most commonly affected: Dachshund, English Setter, English Springer Spaniel, Greyhound, Pembroke Welsh Corgi, Saint Bernard, Beagle, Boxer.