Giant Axonal Neuropathy(GAN)
Also known as: Riesenaxon-Neuropathie · Canine Giant Axonal Neuropathy · Giant Axonal Degeneration
Overview
What it is
Giant axonal neuropathy is a severe, inherited disease of the nervous system where the nerve fibers, called axons, become abnormally swollen and enlarged. This swelling disrupts the normal transmission of electrical signals between the brain and the rest of the body. Over time, this blockage leads to progressive nerve damage and muscle weakness.
How it presents
Symptoms typically appear around one year of age, starting as weakness and uncoordinated movement in the hind legs. This progressive weakness eventually spreads to the front limbs, leading to muscle loss and difficulty swallowing.
Treatment
There is no cure for this condition, and treatment is limited to supportive care to keep the dog comfortable. Diagnostic nerve biopsies and palliative management generally cost between 1,000 and 3,500 EUR, with euthanasia often required as the disease progresses.
How it's tested
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Giant Axonal Neuropathy?
Giant axonal neuropathy is a severe, inherited disease of the nervous system where the nerve fibers, called axons, become abnormally swollen and enlarged. This swelling disrupts the normal transmission of electrical signals between the brain and the rest of the body. Over time, this blockage leads to progressive nerve damage and muscle weakness.
How is Giant Axonal Neuropathy tested?
Various clinical and genetic tests are used depending on the breed and presentation.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.