Neuronal ceroid lipofuscinosis, 8(NCL8)
Also known as: Neuronal ceroid lipofuscinosis type 8 · CLN8 disease · Ceroid-Lipofuszinose Typ 8 · Canine NCL8 · Neuronal Ceroid Lipofuscinosis CLN8
Overview
What it is
Neuronal ceroid lipofuscinosis type 8 (NCL8) is an inherited metabolic disorder affecting the central nervous system. It is caused by a genetic defect that prevents cells from breaking down cellular waste products, leading to a harmful buildup in the brain's nerve cells. Over time, this accumulation causes progressive and irreversible damage to the brain tissue.
How it presents
Symptoms typically appear between 1 and 2 years of age, starting with vision loss, coordination issues, and noticeable behavioral changes. As the disease advances, dogs often experience seizures and a severe decline in mental and physical capabilities.
Treatment
There is no cure for this progressive disease, so treatment focuses entirely on palliative care and managing seizures with medication. Providing supportive care to keep the dog comfortable typically costs between 1,000 and 4,000 EUR.
How it's tested
NCL8 DNA-Test(NCL8)
Primary testDNA testEin molekularbiologischer DNA-Test identifiziert die ursächliche Mutation im CLN8-Gen, um betroffene Hunde sowie symptomfreie Anlageträger (Träger) eindeutig zu bestimmen.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Neuronal ceroid lipofuscinosis, 8?
Neuronal ceroid lipofuscinosis type 8 (NCL8) is an inherited metabolic disorder affecting the central nervous system. It is caused by a genetic defect that prevents cells from breaking down cellular waste products, leading to a harmful buildup in the brain's nerve cells. Over time, this accumulation causes progressive and irreversible damage to the brain tissue.
How is Neuronal ceroid lipofuscinosis, 8 tested?
Tests currently in our database: NCL8 DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.