Lupoid dermatosis(ECLE)
Also known as: Exfoliative cutaneous lupus erythematosus · Lupoide Dermatose · Hereditary lupoid dermatosis · Lupoid dermatosis of German Shorthaired Pointers
Overview
What it is
Lupoid dermatosis is an inherited autoimmune skin disease where a dog's immune system mistakenly attacks and destroys its own skin cells. This abnormal immune response targets the outer layers of the skin, leading to severe, chronic inflammation and tissue damage. Over time, this causes significant scaling, crusting, and hair loss across the body.
How it presents
Symptoms typically begin to show around six months of age. Owners will likely notice painful crusts, scaling, and hair loss starting on the head and legs, which can progress to nail loss and fever.
Treatment
This condition is incurable and often responds poorly to therapy, requiring lifelong management with immunosuppressive medications and specialized veterinary care. The lifetime cost of managing this severe disease typically ranges from €2,000 to €8,000.
How it's tested
ECLE DNA-Test(ECLE)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation im UNC93B1-Gen, die für die exfoliative kutane Lupus erythematodes (ECLE) beim Deutsch Kurzhaar verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Lupoid dermatosis?
Lupoid dermatosis is an inherited autoimmune skin disease where a dog's immune system mistakenly attacks and destroys its own skin cells. This abnormal immune response targets the outer layers of the skin, leading to severe, chronic inflammation and tissue damage. Over time, this causes significant scaling, crusting, and hair loss across the body.
How is Lupoid dermatosis tested?
Tests currently in our database: ECLE DNA-Test.
Which breeds are most affected?
Most commonly affected: German Shorthaired Pointer, Hungarian Vizsla.