TP53-related cancer(TP53)
Also known as: TP53-associated cancer · Li-Fraumeni-like syndrome · TP53 hereditary cancer · TP53-assoziierter Krebs · TP53 tumor suppressor deficiency · …
Overview
What it is
This condition is an inherited predisposition to cancer caused by a mutation in the TP53 gene. This gene normally acts as a tumor suppressor, meaning it produces a protein that regulates cell division and prevents damaged cells from multiplying. Without this functioning protective system, dogs are highly susceptible to developing various aggressive tumors throughout the body.
How it presents
Affected dogs often develop aggressive cancers, such as bone cancer or lymphoma, typically at a young or middle age. Owners may notice signs such as persistent lameness, unusual swellings, unexplained weight loss, or a sudden drop in energy levels.
Treatment
While the genetic predisposition itself cannot be cured, the resulting tumors are managed with intensive treatments like surgery or chemotherapy to extend the dog's life. These complex medical interventions are costly, with typical treatment expenses ranging from €3,000 to €10,000.
How it's tested
TP53 DNA-Test(TP53)
Primary testDNA testDer DNA-Test identifiziert Mutationen im TP53-Tumorsuppressorgen, die mit einem erhöhten Risiko für verschiedene Krebsarten assoziiert sind.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is TP53-related cancer?
This condition is an inherited predisposition to cancer caused by a mutation in the TP53 gene. This gene normally acts as a tumor suppressor, meaning it produces a protein that regulates cell division and prevents damaged cells from multiplying. Without this functioning protective system, dogs are highly susceptible to developing various aggressive tumors throughout the body.
How is TP53-related cancer tested?
Tests currently in our database: TP53 DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.