Ichthyosis, ALOXE3-related(ARCI)
Also known as: ALOXE3-related ichthyosis · Autosomal recessive congenital ichthyosis · ARCI-ALOXE3 · Fischschuppenkrankheit · ALOXE3-Ichthyose
Overview
What it is
This is an inherited skin disorder caused by a genetic mutation that disrupts the skin's natural protective barrier. Without this barrier, the skin cannot retain moisture properly, leading to a severe buildup of dry, scaly skin cells, a process called hyperkeratosis. This condition specifically affects the outer layer of the skin and is inherited in an autosomal-recessive manner.
How it presents
Owners will typically notice symptoms starting in puppyhood, characterized by dry skin, a coarse coat, and large, often dark scales. Affected dogs are also prone to frequent itching and secondary, painful skin infections.
Treatment
While the condition is incurable and requires lifelong management, it can be controlled with regular medicated baths and moisturizing treatments. The lifetime cost of this supportive care typically ranges from 2,000 to 7,000 EUR.
How it's tested
ALOXE3-Ichthyose DNA-Test(ALOXE3)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der ursächlichen Mutation im ALOXE3-Gen, die für die autosomal-rezessive Ichthyose verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Ichthyosis, ALOXE3-related?
This is an inherited skin disorder caused by a genetic mutation that disrupts the skin's natural protective barrier. Without this barrier, the skin cannot retain moisture properly, leading to a severe buildup of dry, scaly skin cells, a process called hyperkeratosis. This condition specifically affects the outer layer of the skin and is inherited in an autosomal-recessive manner.
How is Ichthyosis, ALOXE3-related tested?
Tests currently in our database: ALOXE3-Ichthyose DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.