GM2 Gangliosidosis Type 1b (Japanese Chin)(GM2-1b)
Also known as: GM2 Gangliosidosis · Tay-Sachs Disease in Japanese Chins · HEXA Deficiency · GM2-Gangliosidose Typ I · GM2-Gangliosidose Japan Chin
Overview
What it is
GM2 Gangliosidosis Type 1b is an inherited metabolic disorder that affects the central nervous system. It is caused by a deficiency in a vital enzyme, which prevents the body from breaking down certain fatty-sugar compounds called gangliosides. As a result, these substances build up to toxic levels inside the brain and nerve cells, causing progressive neurological damage.
How it presents
Symptoms typically begin between 3 and 4 months of age, starting with coordination problems, tremors, and vision loss. These signs progress rapidly until the dog is no longer able to stand.
Treatment
This condition is incurable and fatal, with veterinary care focusing entirely on comfort and palliative support. Managing the dog's comfort and eventual euthanasia typically costs between 500 and 2000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is GM2 Gangliosidosis Type 1b (Japanese Chin)?
GM2 Gangliosidosis Type 1b is an inherited metabolic disorder that affects the central nervous system. It is caused by a deficiency in a vital enzyme, which prevents the body from breaking down certain fatty-sugar compounds called gangliosides. As a result, these substances build up to toxic levels inside the brain and nerve cells, causing progressive neurological damage.
How is GM2 Gangliosidosis Type 1b (Japanese Chin) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Shiba Inu.