Familial Nephropathy(JEB)
Also known as: Hereditary Nephropathy · FN · Alport Syndrome · Familiäre Nierenerkrankung · Familiäre Nephropathie · …
Overview
What it is
Familial Nephropathy (FN) is an inherited kidney disease caused by a genetic defect in collagen, which is a vital structural protein. This defect damages the kidneys' filtering units, preventing them from properly removing waste products from the blood. Over time, this leads to progressive and irreversible kidney failure.
How it presents
Affected dogs typically show symptoms between 6 months and 2 years of age. Owners may notice signs of kidney dysfunction, such as excessive thirst, frequent urination, weight loss, vomiting, and general weakness.
Treatment
The disease is incurable and ultimately fatal, though supportive therapy can temporarily manage symptoms and maintain comfort. Managing this condition typically costs between 1,000 and 4,000 EUR before humane euthanasia becomes necessary.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Protein-Losing-Nephropathy (PLN) DNA-Test(PLN)
Primary testDNA testDer DNA-Test identifiziert Risikovarianten in den Genen NPHS1 und KIRREL2, die maßgeblich mit der Entstehung der Protein-Losing-Nephropathie beim Soft Coated Wheaten Terrier assoziiert sind.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Familiäre Nephropathie (FN) DNA-Test(FN)
Primary testDNA testEin Gentest, der die Mutation im COL4A4-Gen nachweist, welche für die Entstehung der familiären Nephropathie verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
15 of 15 breeds
Mandatory testCocker Spaniel
Mandatory testStaffordshire Bull TerrierMandated by Deutscher Club für Bullterrier e.V.
RecommendedBernese Mountain Dog
RecommendedBull Terrier
RecommendedCockapoo
RecommendedDobermann
RecommendedIrish Soft Coated Wheaten Terrier
RecommendedLhasa Apso
RecommendedNorwegian Elkhound
RecommendedPembroke Welsh Corgi
RecommendedRottweiler
RecommendedSamoyed
RecommendedShar-Pei
RecommendedShih Tzu
OptionalWelsh Springer Spaniel
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Familial Nephropathy?
Familial Nephropathy (FN) is an inherited kidney disease caused by a genetic defect in collagen, which is a vital structural protein. This defect damages the kidneys' filtering units, preventing them from properly removing waste products from the blood. Over time, this leads to progressive and irreversible kidney failure.
How is Familial Nephropathy tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Protein-Losing-Nephropathy (PLN) DNA-Test, Familiäre Nephropathie (FN) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Cocker Spaniel, Staffordshire Bull Terrier, Bernese Mountain Dog, Bull Terrier, Cockapoo, Dobermann, Irish Soft Coated Wheaten Terrier, Lhasa Apso.