Ectodermal Dysplasia(ED-SFS)
Also known as: Ectodermal Dysplasia-Skin Fragility Syndrome · Ektodermale Dysplasie · Skin Fragility Syndrome · Chesapeake Bay Retriever Skin Fragility Syndrome · Ektodermale Dysplasie und Hautfragilitätssyndrom · …
Overview
What it is
Ectodermal dysplasia with skin fragility syndrome (ED-SFS) is a severe genetic disorder affecting the skin and its associated structures, such as hair, claws, and teeth. It is caused by a defect in the proteins that normally bind skin cells together, leading to extremely weak cell cohesion. This lack of structural integrity makes the skin highly vulnerable to tearing and peeling under normal wear and tear.
How it presents
Symptoms typically appear in puppyhood, often as soon as the puppy begins interacting with littermates. Owners will notice extremely fragile skin that tears or blisters easily, patchy hair loss, malformed claws, and missing or abnormal teeth.
Treatment
There is no cure for this condition, and management requires lifelong, intensive wound care and protective measures to prevent skin damage. Treatment focuses on managing recurring infections and protecting the skin, with lifetime costs typically ranging from 3,000 to 12,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
XHED DNA-Test(XHED)
Primary testDNA testEin DNA-Test zum Nachweis der Mutation im EDA-Gen, die fuer die x-chromosomal rezessive hypohidrotische ektodermale Dysplasie verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Ektodermale Dysplasie / Hautfragilitäts-Syndrom (ED-SFS) DNA-Test(ED-SFS)
Primary testDNA testEin DNA-Test identifiziert die Mutation im PKP1-Gen, die für das Ektodermale Dysplasie-Hautfragilitäts-Syndrom verantwortlich ist, und ermöglicht den Nachweis von betroffenen Hunden und symptomfreien Trägern.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
2 of 2 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Ectodermal Dysplasia?
Ectodermal dysplasia with skin fragility syndrome (ED-SFS) is a severe genetic disorder affecting the skin and its associated structures, such as hair, claws, and teeth. It is caused by a defect in the proteins that normally bind skin cells together, leading to extremely weak cell cohesion. This lack of structural integrity makes the skin highly vulnerable to tearing and peeling under normal wear and tear.
How is Ectodermal Dysplasia tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), XHED DNA-Test, Ektodermale Dysplasie / Hautfragilitäts-Syndrom (ED-SFS) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Whippet, Miniature Poodle.