Ehlers-Danlos syndrome variant 2(EDS)
Also known as: Ehlers-Danlos Syndrome Type II · Cutaneous asthenia · Dermatoparaxis · Rubber skin disease · Kollagendysplasie · …
Overview
What it is
Ehlers-Danlos syndrome variant 2 is an inherited connective tissue disorder affecting the structural integrity of the skin and joints. It is caused by a genetic defect in tenascin-X, a protein that helps support the body's tissues, and is inherited in an autosomal-recessive manner. This defect leads to a lack of strength in the skin, making it exceptionally fragile and elastic.
How it presents
Owners will typically notice extremely loose, stretchy, and fragile skin starting in puppyhood. The skin tears easily during normal play or minor snags, heals slowly, and is highly prone to developing severe wounds.
Treatment
While the condition is incurable and requires lifelong management to prevent injuries, wounds can be treated as they arise. Lifetime care, including protective wear and frequent veterinary wound management, typically costs between €1,500 and €6,000.
How it's tested
Ehlers-Danlos-Syndrom (EDS) DNA-Test(EDS)
Primary testDNA testEin molekularbiologischer DNA-Test identifiziert die spezifische Mutation im Kollagen-Gen, welche für das Ehlers-Danlos-Syndrom Variante 2 verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Ehlers-Danlos syndrome variant 2?
Ehlers-Danlos syndrome variant 2 is an inherited connective tissue disorder affecting the structural integrity of the skin and joints. It is caused by a genetic defect in tenascin-X, a protein that helps support the body's tissues, and is inherited in an autosomal-recessive manner. This defect leads to a lack of strength in the skin, making it exceptionally fragile and elastic.
How is Ehlers-Danlos syndrome variant 2 tested?
Tests currently in our database: Ehlers-Danlos-Syndrom (EDS) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.