Primary ciliary dyskinesia (PCD), NME5-related(PCD)
Also known as: Primary Ciliary Dyskinesia · Immotile Cilia Syndrome · Ziliendyskinesie · NME5-related PCD
Overview
What it is
Primary ciliary dyskinesia is an inherited respiratory disease caused by a genetic mutation that affects the cilia, which are tiny, hair-like structures lining the airways. In affected dogs, these cilia are malformed or unable to move properly, preventing them from clearing mucus, dust, and bacteria out of the lungs and nasal passages. This failure of the respiratory clearance system leads to chronic airway irritation and recurrent infections.
How it presents
Symptoms typically appear in puppyhood and include a chronic cough, thick nasal discharge, and recurrent bouts of pneumonia. Owners may also notice that affected puppies have difficulty breathing or tire more easily than their littermates.
Treatment
This is an incurable, lifelong condition that requires daily supportive care, including inhalation therapy, mucus-thinning medications, and frequent antibiotics for secondary infections. Managing these chronic respiratory issues over the dog's lifetime is estimated to cost between 4,000 and 15,000 EUR.
How it's tested
Primäre Ciliäre Dyskinesie (NME5) DNA-Test(PCD (NME5))
Primary testDNA testDieser Gentest identifiziert die ursächliche Mutation im NME5-Gen, um betroffene Hunde und Anlageträger der primären ciliären Dyskinesie frühzeitig zu erkennen.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Primary ciliary dyskinesia (PCD), NME5-related?
Primary ciliary dyskinesia is an inherited respiratory disease caused by a genetic mutation that affects the cilia, which are tiny, hair-like structures lining the airways. In affected dogs, these cilia are malformed or unable to move properly, preventing them from clearing mucus, dust, and bacteria out of the lungs and nasal passages. This failure of the respiratory clearance system leads to chronic airway irritation and recurrent infections.
How is Primary ciliary dyskinesia (PCD), NME5-related tested?
Tests currently in our database: Primäre Ciliäre Dyskinesie (NME5) DNA-Test.
Which breeds are most affected?
Most commonly affected: Old English Sheepdog.