Cerebellar abiotrophy, VMP1-related(CA)
Also known as: VMP1-related cerebellar ataxia · Cerebellar cortical degeneration · VMP1-CA · Kleinhirnabiotrophie · Cerebelläre Abiotrophie · …
Overview
What it is
This is an inherited neurological disorder where cells in the cerebellum, the part of the brain that coordinates movement, prematurely degenerate. Because the brain tissue cannot repair itself, this leads to a progressive loss of motor control. This specific form of the disease is caused by a genetic variant in the VMP1 gene.
How it presents
Symptoms typically appear between 4 and 16 months of age, particularly in Australian Working Kelpies and Border Collies. Owners will notice a progressive loss of balance, head tremors, and an increasingly clumsy or uncoordinated gait.
Treatment
There is no cure for this condition, and management is limited to supportive care. Diagnostic and supportive care costs typically range from 500 to 2000 EUR, and euthanasia is often eventually elected due to the severity of the decline.
How it's tested
VMP1-assoziierte zerebelläre Abiotrophie DNA-Test(CA (VMP1))
Primary testDNA testEin DNA-Test zum Nachweis der Mutation im VMP1-Gen, die für die zerebelläre Abiotrophie verantwortlich ist, um Träger und betroffene Hunde zu identifizieren.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Cerebellar abiotrophy, VMP1-related?
This is an inherited neurological disorder where cells in the cerebellum, the part of the brain that coordinates movement, prematurely degenerate. Because the brain tissue cannot repair itself, this leads to a progressive loss of motor control. This specific form of the disease is caused by a genetic variant in the VMP1 gene.
How is Cerebellar abiotrophy, VMP1-related tested?
Tests currently in our database: VMP1-assoziierte zerebelläre Abiotrophie DNA-Test.
Which breeds are most affected?
Most commonly affected: Hungarian Vizsla.