Shar-Pei Autoinflammatory Disease (SPAID)(SPAID)
Also known as: Shar-Pei Autoinflammatory Disease · Shar-Pei-Fieber · Familial Shar-Pei Fever · FSF · Shar-Pei Fever Syndrome · …
Overview
What it is
This is a hereditary systemic inflammatory disorder where the dog's innate immune system mistakenly triggers inflammation without an actual infection. It primarily affects multiple organs and tissues, particularly the skin, joints, and kidneys, due to a genetic mutation linked to the breed's characteristic wrinkled skin. Over time, this chronic inflammation can cause a harmful buildup of proteins in vital organs like the kidneys.
How it presents
Symptoms usually first appear before the age of two, presenting as sudden, recurring bouts of high fever and painful joint swelling, particularly in the hocks. Owners may also notice that the dog's muzzle becomes swollen and sensitive to the touch.
Treatment
The disease is incurable and requires lifelong daily medication to manage inflammation and prevent organ damage. Regular veterinary checkups and bloodwork are necessary, with lifetime treatment costs typically ranging from €3,000 to €12,000.
How it's tested
SPAID DNA-Test(SPAID)
Primary testDNA testDer DNA-Test analysiert genetische Varianten (wie im MTBP-Gen), um das Risiko für die Shar-Pei Autoinflammatorische Erkrankung und die damit verbundene Amyloidose zu bestimmen.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
SPAID DNA-Test(SPAID)
Primary testDNA testDer DNA-Test untersucht die genetische Mutation, die für das Shar-Pei Autoinflammatory Disease (SPAID) verantwortlich ist, um das Risiko für Fieberschübe und Amyloidose zu bestimmen.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Nierenbiopsie und Urinanalyse(Nierenbiopsie)
Primary testClinical examDie Diagnose der IgA-Glomerulonephropathie wird durch eine histopathologische Untersuchung einer Nierenbiopsie mittels Immunfluoreszenz zum Nachweis von IgA-Depots sowie durch Urinanalysen (Proteinurie) gesichert.
Issuing body: vet
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Shar-Pei Autoinflammatory Disease (SPAID)?
This is a hereditary systemic inflammatory disorder where the dog's innate immune system mistakenly triggers inflammation without an actual infection. It primarily affects multiple organs and tissues, particularly the skin, joints, and kidneys, due to a genetic mutation linked to the breed's characteristic wrinkled skin. Over time, this chronic inflammation can cause a harmful buildup of proteins in vital organs like the kidneys.
How is Shar-Pei Autoinflammatory Disease (SPAID) tested?
Tests currently in our database: SPAID DNA-Test, SPAID DNA-Test, Nierenbiopsie und Urinanalyse.
Which breeds are most affected?
Most commonly affected: Shar-Pei.