Alaskan Husky Encephalopathy(AHE)
Also known as: SLC19A3 encephalopathy · Subacute necrotizing encephalomyelopathy · Thiamine transporter 2 deficiency · AHE of Alaskan Huskies · SLC19A3-associated encephalopathy
Overview
What it is
Alaskan Husky Encephalopathy is an inherited brain disease caused by a genetic mutation that disrupts how the body transports thiamine (vitamin B1). Without proper thiamine transport, the brain cannot process energy correctly, leading to progressive damage to nerve tissues. This is an autosomal-recessive condition, meaning a puppy must inherit the mutated gene from both parents to develop the disease.
How it presents
Symptoms typically appear in young dogs between a few months and two years of age. Owners may notice seizures, sudden blindness, difficulty coordinating movements, and unusual behavioral changes.
Treatment
There is no cure for this condition, and supportive care to manage symptoms typically costs between 1,000 and 3,000 EUR. Because the disease is progressive and severely impacts quality of life, humane euthanasia is often eventually required.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Alaskan Husky Enzephalopathie (AHE) DNA-Test(AHE)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation im SLC19A3-Gen, um betroffene Hunde und symptomfreie Träger der Alaskan Husky Enzephalopathie sicher zu bestimmen.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Alaskan Husky Encephalopathy?
Alaskan Husky Encephalopathy is an inherited brain disease caused by a genetic mutation that disrupts how the body transports thiamine (vitamin B1). Without proper thiamine transport, the brain cannot process energy correctly, leading to progressive damage to nerve tissues. This is an autosomal-recessive condition, meaning a puppy must inherit the mutated gene from both parents to develop the disease.
How is Alaskan Husky Encephalopathy tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Alaskan Husky Enzephalopathie (AHE) DNA-Test, Embark Breed + Health Panel, MyDogDNA Panel, Feragen Komplettpaket (rassespezifisch).
Which breeds are most affected?
Most commonly affected: Alaskan Husky.