Dwarfism, PRKG2-related(PRKG2)
Also known as: PRKG2 dwarfism · PRKG2-related dwarfism · Osteochondrodysplasia PRKG2-related · Disproportionate dwarfism PRKG2 · PRKG2-Zwergwuchs · …
Overview
What it is
This is an inherited skeletal disorder caused by a genetic mutation in the PRKG2 gene, which impairs normal bone and cartilage development. The mutation disrupts the skeletal system's growth plates, preventing the long bones in the limbs from growing to their proper length. This leads to disproportionate dwarfism, where the dog's legs are abnormally short compared to the rest of its body.
How it presents
Owners will typically notice signs within the first few weeks of a puppy's life, as they fail to grow at a normal rate and develop short, sometimes bowed legs. The puppy may also have a disproportionately large head and, as they age, develop joint stiffness, pain, and difficulty moving.
Treatment
There is no cure for this genetic condition, meaning treatment is lifelong and focuses on managing pain and supporting joint health. Managing this condition typically costs between 1,500 and 6,000 EUR over the dog's lifetime for supportive therapies, pain medications, and veterinary monitoring.
How it's tested
PRKG2-Zwergwuchs DNA-Test(PRKG2)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der ursächlichen Mutation im PRKG2-Gen, die zu disproportionierter Zwergwuchsform führt.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Dwarfism, PRKG2-related?
This is an inherited skeletal disorder caused by a genetic mutation in the PRKG2 gene, which impairs normal bone and cartilage development. The mutation disrupts the skeletal system's growth plates, preventing the long bones in the limbs from growing to their proper length. This leads to disproportionate dwarfism, where the dog's legs are abnormally short compared to the rest of its body.
How is Dwarfism, PRKG2-related tested?
Tests currently in our database: PRKG2-Zwergwuchs DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.