VLDLR-associated cerebellar hypoplasia(VLDLR-CH)
Also known as: Cerebelläre Hypoplasie (VLDLR-Typ) · Eurasier cerebellar hypoplasia · Cerebellar ataxia VLDLR-associated · Dandy-Walker-Like Malformation · Dandy-Walker-ähnliche Missbildung · …
Overview
What it is
This is an inherited neurological condition where the cerebellum, the part of the brain that controls balance and coordination, fails to develop fully. It is caused by a genetic mutation that disrupts normal brain development during gestation. Because of this underdevelopment, the dog's nervous system cannot properly coordinate voluntary movements.
How it presents
Symptoms usually become noticeable when puppies start walking, typically between 3 and 6 weeks of age. Owners will observe a wobbly or uncoordinated gait, frequent loss of balance, and head tremors, though these signs generally do not worsen as the dog grows.
Treatment
There is no cure for this condition, but because it is non-progressive, affected dogs can live a comfortable life with lifelong supportive care and home modifications. Managing these special needs and ensuring a safe environment typically involves lifetime costs ranging from 1,000 to 5,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
VLDLR-CH DNA-Test(VLDLR-CH)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der ursächlichen Mutation im VLDLR-Gen, die für die zerebelläre Hypoplasie verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is VLDLR-associated cerebellar hypoplasia?
This is an inherited neurological condition where the cerebellum, the part of the brain that controls balance and coordination, fails to develop fully. It is caused by a genetic mutation that disrupts normal brain development during gestation. Because of this underdevelopment, the dog's nervous system cannot properly coordinate voluntary movements.
How is VLDLR-associated cerebellar hypoplasia tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), VLDLR-CH DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Eurasier.