Cerebellar Degeneration (Setter)(HA/CA)
Also known as: Cerebellar Cortical Degeneration · CCD · Hereditary Ataxia · Cerebellar Ataxia · Kleinhirndegeneration · …
Overview
What it is
This is an inherited neurological disorder where nerve cells in the cerebellum, the part of the brain responsible for coordinating movement, prematurely break down and die. In Gordon Setters, this degeneration is linked to a specific genetic mutation and is inherited in an autosomal-recessive manner, meaning a puppy must inherit the gene from both parents to be affected.
How it presents
Owners typically notice symptoms between a few months and four years of age, starting with an unsteady, clumsy gait and a loss of balance. Over time, these signs progress to noticeable tremors, difficulty standing, and a lack of coordination during normal activities.
Treatment
There is no cure for this progressive condition, and supportive care is aimed at maintaining comfort. Managing the disease and associated veterinary evaluations typically costs between 500 and 2000 EUR, though humane euthanasia is often considered as quality of life declines.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Cerebellar Degeneration (Setter)?
This is an inherited neurological disorder where nerve cells in the cerebellum, the part of the brain responsible for coordinating movement, prematurely break down and die. In Gordon Setters, this degeneration is linked to a specific genetic mutation and is inherited in an autosomal-recessive manner, meaning a puppy must inherit the gene from both parents to be affected.
How is Cerebellar Degeneration (Setter) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Spinone Italiano.