Vitamin D-dependent rickets(HVDRR)
Also known as: Hereditary Vitamin D-Resistant Rickets · VDDR · Vitamin-D-abhängige Rachitis Typ II · Vitamin D Receptor Defect · Vitamin D-deficiency rickets, type IA · …
Overview
What it is
This inherited metabolic disorder prevents the dog's body from properly processing vitamin D or responding to its receptors. Without functioning vitamin D pathways, the skeletal system cannot absorb calcium, which is essential for building strong bones. This failure leads to severely weakened, soft, and poorly mineralized bone tissue.
How it presents
Symptoms typically become noticeable in early puppyhood as the skeleton develops. Owners may observe stunted growth, bowed legs, a stiff or painful gait, and extreme sensitivity to being touched or handled.
Treatment
The condition is incurable and requires lifelong daily management with specialized vitamin D supplements and calcium. Regular veterinary checkups and blood tests are necessary to monitor levels, with lifetime treatment costs ranging from 3,000 to 12,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Vitamin D-dependent Rickets Type IA (VDDR1A) Gentest(VDDR1A)
Primary testDNA testDieser Gentest identifiziert die ursächliche Mutation im CYP27B1-Gen, um betroffene Hunde und symptomfreie Träger der Vitamin-D-abhängigen Rachitis Typ IA zu identifizieren.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
Vitamin D-deficiency rickets, type II (HVDRR) DNA-Test(HVDRR)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation im VDR-Gen, die für die Vitamin-D-resistente Rachitis Typ II verantwortlich ist, und ermöglicht den Nachweis von betroffenen und Trägertieren.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Vitamin D-dependent rickets?
This inherited metabolic disorder prevents the dog's body from properly processing vitamin D or responding to its receptors. Without functioning vitamin D pathways, the skeletal system cannot absorb calcium, which is essential for building strong bones. This failure leads to severely weakened, soft, and poorly mineralized bone tissue.
How is Vitamin D-dependent rickets tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Vitamin D-dependent Rickets Type IA (VDDR1A) Gentest, Vitamin D-deficiency rickets, type II (HVDRR) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.