Verrucous epidermal keratinocytic nevi
Also known as: Epidermal nevus · Linear epidermal nevus · Verrucous epidermal nevus · Keratinocytic nevus · Epidermaler Naevus · …
Overview
What it is
This is an inherited skin disorder caused by a genetic mutation in the NSDHL gene, which is passed down on the X chromosome. The mutation affects the development of keratinocytes, which are the cells that make up the outer layer of the skin, leading to abnormal, wart-like growths. Because of how it is inherited, the condition is typically fatal for male puppies before birth, while affected female puppies develop skin issues and associated lameness.
How it presents
The condition typically appears in puppies or young dogs as raised, linear, and often darkened wart-like skin lesions. Owners may also notice signs of discomfort, skin infections, or lameness if the lesions develop on the limbs or paws.
Treatment
Although there is no cure, localized lesions can be managed or removed using surgery or laser therapy, alongside antiseptic treatments for secondary infections. Lifelong management of symptoms typically costs between 300 and 2000 EUR.
How it's tested
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Verrucous epidermal keratinocytic nevi?
This is an inherited skin disorder caused by a genetic mutation in the NSDHL gene, which is passed down on the X chromosome. The mutation affects the development of keratinocytes, which are the cells that make up the outer layer of the skin, leading to abnormal, wart-like growths. Because of how it is inherited, the condition is typically fatal for male puppies before birth, while affected female puppies develop skin issues and associated lameness.
How is Verrucous epidermal keratinocytic nevi tested?
Various clinical and genetic tests are used depending on the breed and presentation.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.