Van den Ende-Gupta syndrome(VDEGS)
Also known as: Van den Ende-Gupta-Syndrom
Overview
What it is
Van den Ende-Gupta syndrome is an inherited developmental disorder that primarily affects the skeletal system, including the skull and joints. It is caused by a genetic mutation that disrupts normal bone and cartilage formation, leading to structural abnormalities. This results in characteristic malformations of the face and limbs.
How it presents
Symptoms are visible from birth or early puppyhood and typically include a noticeably shortened upper jaw, abnormally formed eyelids, and stiff joints. Owners may also observe difficulty walking or running due to kneecaps that slip out of place.
Treatment
While the underlying condition is incurable, symptoms can be managed through corrective orthopedic surgeries and ongoing physical therapy. These lifelong supportive care measures and surgical procedures typically cost between 3,000 and 10,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Van den Ende-Gupta syndrome?
Van den Ende-Gupta syndrome is an inherited developmental disorder that primarily affects the skeletal system, including the skull and joints. It is caused by a genetic mutation that disrupts normal bone and cartilage formation, leading to structural abnormalities. This results in characteristic malformations of the face and limbs.
How is Van den Ende-Gupta syndrome tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel, Feragen Komplettpaket (rassespezifisch).
Which breeds are most affected?
Most commonly affected: Fox Terrier, Wire Fox Terrier.