Trapped Neutrophil Syndrome(TNS)
Also known as: Trapped Neutrophil Syndrom · Neutrophilensyndrom · VPS13B-Defizienz · Border Collie Immunschwäche · Trapped Neutrophil Syndrome (Border Collie) · …
Overview
What it is
Trapped Neutrophil Syndrome (TNS) is an inherited immune system disorder where the bone marrow produces white blood cells, called neutrophils, but is unable to release them into the bloodstream. Because these neutrophils are essential for fighting off bacteria and viruses, their absence leaves the dog's body highly vulnerable to infections. This genetic defect is inherited in an autosomal-recessive manner, meaning a puppy must receive the mutated gene from both parents to develop the condition.
How it presents
Symptoms typically appear in puppies within the first few weeks to months of life. Owners will usually notice chronic, recurring infections that do not heal properly, accompanied by fever, joint pain, and a general failure to grow at a normal rate.
Treatment
There is no cure for this severe condition, and therapy is limited to lifelong supportive care and antibiotics to manage infections. This ongoing medical management is generally unsuccessful long-term and typically costs between 1,000 and 5,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Trapped Neutrophil Syndrome DNA-Test(TNS)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der Mutation im VPS13B-Gen, die für das Trapped Neutrophil Syndrome verantwortlich ist.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Trapped Neutrophil Syndrome?
Trapped Neutrophil Syndrome (TNS) is an inherited immune system disorder where the bone marrow produces white blood cells, called neutrophils, but is unable to release them into the bloodstream. Because these neutrophils are essential for fighting off bacteria and viruses, their absence leaves the dog's body highly vulnerable to infections. This genetic defect is inherited in an autosomal-recessive manner, meaning a puppy must receive the mutated gene from both parents to develop the condition.
How is Trapped Neutrophil Syndrome tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Trapped Neutrophil Syndrome DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.