TUBB1-related macrothrombocytopenia
Also known as: Thrombocytopenia, TUBB1-related
Overview
What it is
This is an inherited blood condition where a genetic mutation affects how platelets, the cells responsible for blood clotting, develop. The body produces fewer platelets than normal, but the ones it does make are abnormally large. Despite these changes in cell size and number, the blood's ability to clot normally is typically not impaired.
How it presents
Dogs with this condition do not show any physical symptoms, such as spontaneous bleeding or bruising, and the trait is present from birth. It is typically discovered as an incidental finding during routine blood tests at any age.
Treatment
No treatment is necessary as this condition is entirely benign and does not affect the dog's quality of life or lifespan. The treatment cost is 0 EUR, and awareness of the condition helps avoid unnecessary medical interventions.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is TUBB1-related macrothrombocytopenia?
This is an inherited blood condition where a genetic mutation affects how platelets, the cells responsible for blood clotting, develop. The body produces fewer platelets than normal, but the ones it does make are abnormally large. Despite these changes in cell size and number, the blood's ability to clot normally is typically not impaired.
How is TUBB1-related macrothrombocytopenia tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.