Deafness, unilateral and vestibular dysfunction, PTPRQ-related
Also known as: PTPRQ-related deafness and vestibular dysfunction · PTPRQ-associated vestibular dysfunction and unilateral deafness · PTPRQ-Taubheit und Vestibulärsyndrom · PTPRQ gene mutation deafness · Unilateral deafness and vestibular dysfunction · …
Overview
What it is
This is an inherited disorder of the inner ear caused by a genetic mutation, commonly known as DINGS1. It affects both the auditory system, which processes sound, and the vestibular system, which is the organ responsible for balance. The mutation prevents the normal development of sensory hair cells in the ear, leading to hearing loss on one side and coordination issues.
How it presents
Symptoms typically become noticeable during early puppyhood as the dog begins to explore. Owners may observe a persistent head tilt, unsteadiness or wobbling while walking, and a failure to react to sounds on one side of their head.
Treatment
While there is no cure, the condition is non-progressive and affected dogs can live high-quality lives with environmental safety adjustments and training. Lifetime management and supportive care costs generally range from 200 to 1200 EUR.
How it's tested
BAER-Hörtest(BAER)
Primary testhearingBrainstem Auditory Evoked Response: objektiver Hörtest, erkennt einseitige und beidseitige Taubheit.
Issuing body: BAER
Result scheme: BAER
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Deafness, unilateral and vestibular dysfunction, PTPRQ-related?
This is an inherited disorder of the inner ear caused by a genetic mutation, commonly known as DINGS1. It affects both the auditory system, which processes sound, and the vestibular system, which is the organ responsible for balance. The mutation prevents the normal development of sensory hair cells in the ear, leading to hearing loss on one side and coordination issues.
How is Deafness, unilateral and vestibular dysfunction, PTPRQ-related tested?
Tests currently in our database: BAER-Hörtest, Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.