Centronuclear myopathy 2, BIN1-related(CNM)
Also known as: Centronuclear Myopathy 2 · BIN1-related centronuclear myopathy · BIN1-CNM · Centronukleäre Myopathie Typ 2 · Centronuclear Myopathy Great Dane · …
Overview
What it is
Centronuclear myopathy 2, also known as IMGD, is an inherited muscle disorder caused by a genetic defect in the BIN1 gene. This mutation disrupts the normal structure of muscle fibers, which are the microscopic building blocks of skeletal muscles. Because these fibers cannot contract properly, the dog's muscles progressively weaken and waste away.
How it presents
Symptoms typically appear during puppyhood, usually between 2 and 6 months of age. Owners will likely notice muscle weakness, a stiff or bunny-hopping gait, rapid fatigue, and visible muscle wasting.
Treatment
There is no cure for this condition, meaning treatment is limited to lifelong supportive care, including physiotherapy and lifestyle adjustments. The estimated lifetime cost for managing this disease ranges from 2,000 to 8,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Centronuclear Myopathy 1 (CNM1) DNA-Test(CNM1)
Primary testDNA testEin molekularbiologischer Gentest identifiziert die ursächliche Mutation im DNM2-Gen, um betroffene Hunde und Anlageträger frühzeitig zu erkennen.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Centronuclear myopathy 2, BIN1-related?
Centronuclear myopathy 2, also known as IMGD, is an inherited muscle disorder caused by a genetic defect in the BIN1 gene. This mutation disrupts the normal structure of muscle fibers, which are the microscopic building blocks of skeletal muscles. Because these fibers cannot contract properly, the dog's muscles progressively weaken and waste away.
How is Centronuclear myopathy 2, BIN1-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Centronuclear Myopathy 1 (CNM1) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Labradoodle.